List of exclusions needed for Exchange Server
For compatibility with Microsoft Exchange, exclude the locations that Microsoft recommends for file-level scanners in the on-access scanner for ENS, VSE, and MSME. For the most accurate list of file exclusions, see the following Microsoft TechNet article: https://social.technet.microsoft.com/wiki/contents/articles/953.microsoft-anti-virus-exclusion-list.aspx. Within the TechNet article, go to the "E" section and click the article link for the version of Exchange in use in your environment. The following is the list of Exchange articles as of January 2021:

• Exchange 2019 - https://docs.microsoft.com/en-us/Exchange/antispam-and-antimalware/windows-antivirus-software?view=exchserver-2019
• Exchange 2016 - https://technet.microsoft.com/en-us/library/bb332342(v=exchg.160).aspx
• Exchange 2013 - https://technet.microsoft.com/en-us/library/bb332342(v=exchg.150).aspx
• Exchange 2010 - https://technet.microsoft.com/en-us/library/bb332342(v=exchg.141).aspx
• Exchange 2007 - https://technet.microsoft.com/en-us/library/bb332342(v=exchg.80).aspx

How to configure exclusions in ENS and VSE for Exchange Server
When you configure exclusions, always apply the principle that the more precise the exclusion, the smaller the potential security risk. For instructions to configure exclusions, see the following documentation:

• "Preventing Threat Prevention from blocking trusted programs, networks, and services" section of the Endpoint Security Threat Prevention Product Guide
• VSE:
  • KB66909 - Endpoint Security/VirusScan Enterprise exclusion articles
  • KB55898 - VirusScan Enterprise Exclusions Explained
  • KB67544 - How to create low-risk and high-risk process exclusions for VirusScan Enterprise 8.x in ePolicy Orchestrator
  • KB50998 - How to manage file and folder exclusions using wildcards
  • KB61000 - Path of a scan item reported by its physical address instead of logical address

Exclusions needed if MSME is installed
The following extra exclusions are needed only if MSME is installed:

• <MSME installation folder> (Default installation folder is C:\Program Files (x86)\McAfee\MSME)
• <MSME defined quarantine folder>\MSMEData (Default defined quarantine folder is %programdata%\McAfee\MSME\Data)
• The following MSME processes:
  • RPCServ.exe
  • SAFeService.exe
  • postgres.exe
  • MaseRulesUpdater.exe