Recent updates to this article

Date	Update
June 25, 2021	Updated the list of Exchange URLs under "Running Windows antivirus software on Exchange servers."

List of exclusions needed for Exchange Server
For compatibility with Microsoft Exchange, exclude the locations that Microsoft recommends. The exclusions apply to file-level scanners in the on-access scanner for ENS, VSE, and MSME. For the most accurate list of file exclusions, see the Microsoft TechNet article. Within the TechNet article, go to the 'E' section and click the article link for the version of Exchange in use in your environment. The list of Exchange articles below was updated in June 2021:

Running Windows antivirus software on Exchange servers:

• Exchange 2019
• Exchange 2016
• Exchange 2013
• Exchange 2010
• Exchange 2007

How to configure exclusions in ENS and VSE for Exchange Server
When you configure exclusions, always apply the principle that the more precise the exclusion, the smaller the potential security risk. For instructions to configure exclusions, see the following documentation:

• ENS:
  • Endpoint Security Threat Prevention Product Guide
    - Preventing Threat Prevention from blocking trusted programs, networks, and services section
• VSE:
  • KB66909 - Endpoint Security/VirusScan Enterprise exclusion articles
  • KB55898 - VirusScan Enterprise Exclusions Explained
  • KB67544 - How to create low-risk and high-risk process exclusions for VirusScan Enterprise 8.x in ePolicy Orchestrator
  • KB50998 - How to manage file and folder exclusions using wildcards
  • KB61000 - Path of a scan item reported by its physical address instead of logical address

Exclusions needed if MSME is installed
The following extra exclusions are needed only if MSME is installed:

• <MSME installation folder> (Default installation folder is C:\Program Files (x86)\McAfee\MSME)
• <MSME defined quarantine folder>\MSMEData (Default defined quarantine folder is %programdata%\McAfee\MSME\Data)
• The following MSME processes:
  • RPCServ.exe
  • SAFeService.exe
  • postgres.exe
  • MaseRulesUpdater.exe