Using VirusScan Enterprise in a Microsoft Cluster environment
VirusScan Enterprise supports a shared disk model and as such, does not interfere with the failover process on a Microsoft Cluster. However, the On Access scanning service is not a cluster service and not installed as a failover group resource.
VirusScan Enterprise installs on each system (or node) in the cluster and scans as it would on any other server. If a node fails, the surviving nodes with VirusScan Enterprise installed continue to operate as usual. The same is true when the node that failed comes back online - the VirusScan Enterprise that is installed on it will operate normally.
Microsoft Knowledge Base article 250355 http://support.microsoft.com/kb/250355
deals with potential issues with AntiVirus software and failover operations on clusters. It also provides troubleshooting tips for these types of issues.
IMPORTANT: McAfee designs its products so as not to impact failover operations. If you have a failover issue believed to be caused by McAfee products, please contact McAfee Technical Support.