McAfee Agent can't be bound to a specific IP address if the computer on which the agent is installed has multiple IP addresses. The Agent binds to the first available IP address provided by the operating system.

NOTE: Any IP addresses other than the one assigned to the primary Network Interface Card (NIC) on a computer is detected as separate Rogue Computers by RSD sensors.
 

On some operating systems, you can force the computer to report the NIC with the external IP address first (Lan1) and the other as the second (Lan2). This action resolves the problem because the agent automatically binds to whichever the operating system reports as the first interface. For more information about which operating systems this action can be applied to, see the Microsoft article at: https://docs.microsoft.com/en-us/windows-server/networking/technologies/network-subsystem/net-sub-interface-metric.

When a client system restarts, if a different IP address is bound first and used by the Agent, you see the following sequence of events on the ePO server:

Problems incurred when a new IP address is bound by McAfee Agent: