You can safely ignore errors with similar numeric values when they occur during an AutoUpdate. McAfee Enterprise will address the cause of these errors in a future release of Security for Exchange.

When this error is generated during an AutoUpdate, MSME experiences no detrimental effects or functional loss of security. The scanning and quarantining of items continue to work as expected, and no action is needed.

IMPORTANT: Multiple 80040230:McEFILEIOERROR errors (one entry per scanned item) and Event ID 2045 Scan Errors appearing in the logs simultaneously, are an indication that a different issue exists. These errors are indicative of either Database corruption or incorrect placement of the Detected Items database.

In these scenarios, see KB73168 to determine how to resolve the issue.