Agent-to-server communication is supported over NAT; however, agent wake-up calls will not work over NAT. 

Use the details in KB59218 to install an ePO server or Agent Handler in the DMZ to manage the external clients, and one in the internal network to manage only the internal network clients.

KB59218 - https://kc.mcafee.com/corporate/index?page=content&id=KB59218 For more resources, visit the ServicePortal and search for related content.

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